Soluble SMART Digest is a very active, highly stable soluble trypsin for fast, reproducible digestions. SMART Digest is now available in a soluble format compatible with more workflows, including solid tissues, gels, and sample pellets, and compatible with deepwell plates for easy automation. This kit is also “backwards compatible” with soluble samples such as plasma, serum, and CSF. Samples are readily processed in deepwell plates and up to 50uL of untreated plasma is readily digested in ≤2 hours.